PhotoSpex

Photochromic Spexin derivatives to study the implication of GALR2 in non-opioid pain pathways



Résumé
Photopharmacology is a rapidly developing field, which uses light-activable (photochromic) ligands to gain spatio-temporal control of therapeutically relevant biological targets. Devoid of the requirement of genetic modification of target proteins, photopharmacology provides a viable alternative to optogenetics with high clinical potential. Photochromic ligands have proven successful in optically controlling ion channels, enzymes and antibiotics, with a very few photopharmacological tools reported for GPCRs. More particularly, no photoswitchable neuropeptide with in vivo activity has been reported to date. The goal of this project is to develop a strategy to generate photoswitchable neuropeptides that could be activated by light in living mice. Moreover, this project is strengthening the collaboration between the Chemistry Unit (UMR7200, LIT) and the Biology Unit (UMR7242, BSC) on a fully integrated chemical biology research program.

Mots-clés
Chemical biology, Photopharmacology, Neuropeptides, Pain, GPCRs

Partenaires du projet

INC
BONNET Dominique
Biotechnology and Cellular Signaling (UMR7200) Illkirch-Graffenstaden France
INSB
Simonin Frédéric
Biotechnology and Cellular Signaling (UMR7242) France
@Arthur Laurent
Crédit photo : @Arthur Laurent