VGLUTs

Les VGLUTs comme nouveaux biomarqueurs/Gluber



Résumé
Glutamate is the major excitatory neurotransmitter of the central nervous system. Before its release, glutamate is accumulated in synaptic vesicles by three carriers named VGLUT1-3. VGLUTs are pivotal actors of excitatory transmission and therefore are involved in all brain functions. Despite their functional importance, their pharmacology is remarkably limited. Obtaining VGLUT specific, potent and biocompatible compounds would enable the control of their activity not only for basic science, but also for diagnostic /or therapeutic purposes. Once radiolabeled, these compounds could be used to visualize glutamatergic systems in vitro or in vivo. The central objective of the GluTAG proposal is to develop the pharmacology of VGLUTs. To reach this aim, we gathered a multidisciplinary consortium combining pharmaco-chemistry and neuroscience. We will identify, produce, radiolabel and characterize high-affinity and specific ligands of VGLUTs.

Mots-clés
Neuropharmacologie, maladies neurologiques, chimie médicinale, faux neurotransmetteurs fluorescents,

Partenaires du projet

INC
PIETRANCOSTA Nicolas
Neuroscience Paris Seine (UMR7203) Paris France
INSB
Daumas Stéphanie
Neuroscience Paris Seine (UMR8246) France
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