Innovations Optiques pour Imager le Cerveau à des échelles inexplorées

A major challenge of modern neuroscience is to study the brain at multiple spatial and temporal scales. In that respect, it is surprising to note that no tools allows studying brain function at high spatial and temporal resolution over a field-of-view of several cortical areas. Optical imaging provides the closest solution, but is still limited by the curvature of the brain and the physiological pulsations. To image the brain at these unexplored spatial extents and spatio-temporal resolutions, we propose to launch an unprecedented collaboration between neuroscience and astronomy. Using optical innovations in astronomy, including curved optics, curved detectors and post-processing techniques and/or adaptive optics, we will produce a cutting-edge tool. This tool will be directly exploited to record the activity of the entire cortical visual system of a non-human primate (macaque, marmoset). Our objective is to demonstrate that this will enable us to understand how propagation waves within and between cortical areas contribute to the processing of sensory information.

Neuroscience, Optical imaging, Non-human, primate, curved optics, adaptive optics

Partenaires du projet

CHAVANE Frederic
Institut de Neurosciences de la Timone (UMR7289) Marseille France
laboratoire d’astrophysique (UMR7326) Marseille France
Institut de Neurosciences de la Timone (UMR7289) Marseille France
Isabelle Racicot
Crédit photo : Isabelle Racicot