ETERNEEEL

SAME MITOCHONDRIA, DIFFERENT LONGEVITIES: WHAT ANTS TELL US ABOUT METABOLIC AGEING? A PROJECT COUPLING EVOLUTIONARY BIOLOGY TO CELLULAR BIOENERGETICS



Résumé
Mitochondria are the remnants of protobacteria that engaged themselves in endo-symbiosis billion years ago. By increasing the efficiency of ATP production derived from oxygen consumption by eukaryotic cells, they opened evolutionary horizons for the radiation of invertebrate, vertebrate and endothermic organisms. However, as there is never free lunch in evolution, this was done at a cost of oxidative stress, putting mitochondria at the crossroads of bioenergetic mechanisms sustaining the Oxidative Stress Theory of Aging (OSA). Still, OSA has weaknesses and the fact that in ants, maternally inherited identical mitochondria lead to different longevities (up to 20 times), moreover in individuals sharing the same genes, is an important one. By merging the bioenergetics knowledge of the UMR 8104 and the ecophysiology and evolution and proteomics background of the UMR 7178, our interdisciplinary project will enable our PhD student, Maïlly Kervela, to be trained at the border of the socioenergetics of ants, and to address how the functioning of ant’s mitochondria, of shared-maternal origin, may have co-evolved with amazingly contrasting lifespans among social casts.

Mots-clés
Ageing, Evolution, Mitochondria, Bioenergetics, ants

Partenaires du projet

IN2P3
CRISCUOLO François
(UMR7178) Strasbourg France
INSB
Bouillaud Frédéric
Mitochondries, bioénergétique, métabolisme et signalisation (UMR8104) France
INC
Bertile Fabrice
Institut Pluridisciplinaire Hubert Curien - Département des Sciences Analytiques (UMR7178) France
Nicolas Busser CNRS
Crédit photo : Nicolas Busser CNRS